Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe, Fusobacterium nucleatum

Peptoids (oligo N-substituted glycines) are peptide analogues, which can be designed to mimic host antimicrobial peptides, with the advantage that they resistant proteolytic degradation. Few studies on efficacy of peptoids have focused Gram negative anaerobic microbes associated clinical infections, commonly recalcitrant antibiotic treatment. We therefore studied cytotoxicity and antibiofilm activity a family against obligate anaerobe Fusobacterium nucleatum, is infections in oral cavity. Two peptoids, peptoid 4 (NaeNpheNphe)4 9 (NahNspeNspe)3 were shown efficacious F. nucleatum biofilms at concentration 1 μM. At this concentration, not cytotoxic human erythrocytes or primary gingival fibroblast cells. merit as future therapeutics for treatment infections.